Analytical Publications

Synthesis of reference standards for emerging sulfonamide PFAS precursors suspected in aqueous film-forming foams via a benzyl intermediate

November 2024: Per- and polyfluoroalkyl substances (PFAS) have been widely studied due to their persistence in the environment and potential risks to wildlife and human health. The identification and analysis of these thousands of compounds in various environmental matrices is crucial for assessing their presence and evaluating potential risks. However, the growing list of suspected PFAS necessitates the synthesis of pure standards, for the development and validation of analytical methods. This study describes the synthesis of ten sulfonamide-based PFAS precursors suspected to be in the environment potentially because of the use of aqueous film forming foams (AFFFs).