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Engineered RNA Controls for Modern Molecular Diagnostics

ZeptoMetrix Phage-Like Particles (PLP) are synthetic, non-infectious particles engineered to encapsulate custom RNA sequences with a protective protein coat. PLP technology delivers safe, stable, and quantifiable controls for assay development, validation, and long-term performance.

How PLP Technology Works

ZeptoMetrix PLPs are produced using controlled recombinant and purification protocols optimized for accuracy and consistency. The resulting protected RNA control performs reliably across molecular and process workflows.

This enables:

  • Custom RNA target design
  • Assembly within a phage-derived protein coat
  • Enzymatic removal of unprotected nucleic acids
  • Analytical validation
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Why Assay Developers Choose PLPs

  • Leak-proof design
  • High stability
  • Uniform performance
  • Customizable
  • Non-infectious
  • Purity

PLP Technical Resources

Download Poster: Innovative Controls for Molecular Diagnostics: Development of Recombinant Phage-like Particles that Encapsulates Target RNA Viral Gene Segments

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Get the Sell Sheet: Phage-Like Particles (PLPs) Technology

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Listen to Podcast Episode: Not Your Average Phage

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Applications Across Molecular Diagnostics

Infectious Disease Diagnostics

Process controls for a broad range of RNA-based pathogens

Oncology & Precision Medicine

cfRNA standards, transcriptomics in liquid and solid biopsy material

Prenatal & Genetic Testing

cfRNA mimics for PLAC4, β-actin, trisomy 21 markers in maternal blood

NGS & Transcriptomics

Traceable, quantitative surrogates for RNA-seq, cfRNA-seq, & metatranscriptomics

Your Partner in RNA Control Solutions

Our scientists partner with you to deliver tailored control solutions that support your next generation of RNA-based assays and applications.

Explore how ZeptoMetrix Phage-Like Particle technology can advance your work and take the next step with a solution designed around your specific needs.

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Frequently Asked Questions About Our Phage-Like Particles (PLPs)

Is PLP customizable?
Yes, PLP is customizable with respect to RNA length, sequence, and molecular barcodes, allowing flexible design for different assay requirements.
Can we use PLP for transcriptomics studies?
Yes, PLP functions effectively as a standardized, stable extraction and reverse‑transcription (RT) control in transcriptomics workflows, including RNA‑seq applications.
Is PLP refrigerator stable?
Yes, Internal stability studies demonstrate that PLP remains stable for at least 12 months under refrigerated (2–8 °C) storage.
Can I leave PLP at room temperature overnight?
Yes, PLP maintains integrity after overnight room‑temperature exposure.
Is PLP leakage‑proof under freeze–thaw conditions?
Yes, PLP tolerates at least three freeze–thaw cycles without detectable RNA leakage.
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