cfDNA Controls
Oncology Controls for Molecular Testing
cfDNA controls or reference standards are highly characterized, biologically relevant materials used to assess the performance of assays that detect somatic mutations in cfDNA via PCR, Next Generation Sequencing (NGS), or other novel readout methods.
Why use cfDNA controls and reagents?
- ZeptoMetrix controls help ensure the accuracy of the highly sensitive assays needed for cfDNA detection in plasma
- Nucleosomal fragmentation results in a range of cfDNA fragment sizes that mimic patient samples
- Available as concentrated DNA in TE buffer or blended into DNA-depleted plasma as a ready-to-use, full-process control
- Highly customizable product configuration
Ensuring accuracy with the ZeptoMetrix ESR1 Control Kit
Explore a recent interview with Dr. Karsten Kleo, a research assistant at Charité – Universitätsmedizin Berlin, Institute of Pathology, on how the ZeptoMetrix ESR1 control was used to support assay development and quality control in their lab.
New Product!
The first comprehensive ESR1 Control covering 16 ESR1 mutations. Comprehensive ESR1 Control Kit for Oncology Testing:
- ESR1 Control Kit (4 Vials + wt control) — Vial 1: S463P, L536H, Y537S, D538G — Vial 2: E380Q, P535H, L536P, Y537C — Vial 3: S463C, L536R, Y537N, K303R — Vial 4: S463F, V534E, L536Q, V422del
cfDNA Controls for Non-Invasive Prenatal Testing (NIPT)
ZeptoMetrix offers patient-like cfDNA reference materials for Trisomy 13, 18, and 21 to support assay development, validation, and routine run QC for NIPT assays.